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Blog

Bioscience breakthroughs, systems thinking, and the policy conditions that make science happen.

01
Bioscience
CAR-T for autoimmune disease: what Erlangen proved and what comes next
University Hospital Erlangen's CAR-T trials in lupus, myositis, and systemic sclerosis didn't just show remission — they rewrote what remission means for autoimmune patients.
BioscienceSystems
02
Bioscience
The first personalized CRISPR therapy: how CHOP and UPenn pulled it off
In 2025, a child with a rare metabolic disorder became the first person treated with a bespoke CRISPR gene therapy designed for their specific mutation. Here is how it happened.
BiosciencePolicy
03
Systems thinking
Framework — What It Takes for a Breakthrough to Happen
This post explores the full ecosystem required for a scientific breakthrough to occur. It is not just the science itself, but the human, financial, institutional, political, and cultural conditions that make it possible.
SystemsPolicy
04
Bioscience
The diagnosis before the cure: what an ME/CFS breakthrough actually requires
ME/CFS affects more people worldwide than MS, Parkinson's, and HIV combined — with no approved treatment, no biomarker, and a fraction of the research funding. What it would actually take to get unstuck.
BiosciencePolicy